Food intake at the “wrong” time desynchonizes the periphery from the brain and is detrimental to metabolic health. But how does the brain sense this disruption? What nuclei and cell types are involved? Can they be harnessed to alleviate the metabolic burden of shift work or jet lag?

Food intake at the “wrong” time desynchonizes the periphery from the brain and is detrimental to behavioral health. But how does the brain sense this disruption? What nuclei and cell types are involved? Can they be harnessed to alleviate the behavioral burden of shift work or jet lag?

The vagus nerve connects the body and brain and has been implicated in transmitting myriad signals between the two. Is the vagus involved in signaling mistimed eating? Is the vagal neurocircuit a therapeutic target for diseases exacerbated by chrono-disruption?